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1

The effects of theanine, as a novel biochemical modulator, on the antitumor activity of adriamycin

Yasuyuki Sadzuka, Tomomi Sugiyama, Atsuo Miyagishima, Yasuo Nozawa, Sadao Hirota

Journal:

Year:

1996

Language:

english

File:

PDF, 884 KB

english, 1996

2

A Spray-Drying Method for Mass Production of Liposomes.

KUKUCHI, Hiroshi, YAMAUCHI, Hitoshi, HIROTA, Sadao

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1991

File:

PDF, 984 KB

1991

3

The effect of caffeine on adriamycin efflux in Ehrlich ascites carcinoma cells.

Sadzuka, Yasuyuki, Iwazaki, Ayano, Miyagishima, Atsuo, Nozawa, Yasuo, Hirota, Sadao

Journal:

Drug Delivery System

Year:

1996

Language:

english

File:

PDF, 1.05 MB

english, 1996

4

Effects of glycophorin and ganglioside GM3 on the blood circulation and tissue distribution of liposomes in rats

Hitoshi Yamauchi, Hiroshi Kikuchi, Kiyoto Yachi, Masahiro Sawada, Munehiro Tomikawa, Sadao Hirota

Journal:

International Journal of Pharmaceutics

Year:

1993

Language:

english

File:

PDF, 781 KB

english, 1993

5

Effects of shear rate in roll mixing on mechanical complex formation of ibuprofen with β-cyclodextrin

Yasuo Nozawa, Kyosuke Suzuki, Yasuyuki Sadzuka, Atsuo Miyagishima, Sadao Hirota

Journal:

Pharmaceutica Acta Helvetiae

Year:

1994

Language:

english

File:

PDF, 402 KB

english, 1994

6

Caffeine Enhances Adriamycin Antitumor Activity in Ehrlich Ascites Carcinoma-Bearing Mice.

SADZUKA, Yasuyuki, MOCHIZUKI, Eiko, IWAZAKI, Ayano, HIROTA, Sadao, TAKINO, Yoshio

Journal:

Biological & Pharmaceutical Bulletin

Year:

1995

File:

PDF, 638 KB

1995

7

Dielectric studies of emulsions of polyol in hydrophobic colloidal silica-oil gel.

KANEKO, HIDEO, HIROTA, SADAO

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1985

File:

PDF, 1.00 MB

1985

8

Synthesis of galactose derivatives that render lectin-induced agglutinating ability to liposomes

Hisashi Yoshioka, Tetsushi Ohmura, Mariko Hasegawa, Sadao Hirota, Masakazu Makino, Mamoru Kamiya

Journal:

Journal of Pharmaceutical Sciences

Year:

1993

Language:

english

File:

PDF, 323 KB

english, 1993

9

Sulfated N -Myristoyl Chitosan as a Surface Modifier of Liposomes

Yoshioka, Hisashi, Kazama, Shunsuke, Tanizawa, Hisayuki, Hirota, Sadao, Kamiya, Mamoru

Journal:

Bioscience Biotechnology and Biochemistry

Year:

1993

Language:

english

File:

PDF, 1.07 MB

english, 1993

10

Expression of monocyte chemotactic and activating factor in rheumatoid arthritis. regulation of its production in synovial cells by interleukin-1 and tumor necrosis factor

Tohru Akahoshi, Chieki Wada, Hirahito Endo, Kazuhisa Hirota, Shigeru Hosaka, Kenji Takagishi, Hirobumi Kondo, Sadao Kashiwazaki, Kouji Matsushima

Journal:

Arthritis & Rheumatism

Year:

1993

Language:

english

File:

PDF, 939 KB

english, 1993

11

Analysis of Non-Newtonian Flow by Falling-Sphere Method

Hirota, Sadao, Takada, Masao

Journal:

Bulletin of the Chemical Society of Japan

Year:

1959

Language:

english

File:

PDF, 5.66 MB

english, 1959

12

If the Fetus Can Vocalize, How Can We Detect It?

Ishii, Takemochi, Horiguchi, Sadao, Kato, Tadaaki, Waturi, Naoshi, Hirose, Michitaka, Hirota, Kohichi

Journal:

Year:

1991

Language:

english

File:

PDF, 1.61 MB

english, 1991

13

Physical properties and tissue distribution of adriamycin encapsulated in polyethyleneglycol-coated liposomes

Yasuyuki Sadzuka, Sadao Hirota

Journal:

Advanced Drug Delivery Reviews

Year:

1997

Language:

english

File:

PDF, 887 KB

english, 1997

14

Intraperitoneal administration of doxorubicin encapsulating liposomes against peritoneal dissemination

Yasuyuki Sadzuka, Sadao Hirota, Takashi Sonobe

Journal:

Toxicology Letters

Year:

2000

Language:

english

File:

PDF, 261 KB

english, 2000

15

Protective effect of flavonoids on doxorubicin-induced cardiotoxicity

Yasuyuki Sadzuka, Tomomi Sugiyama, Kayoko Shimoi, Naohide Kinae, Sadao Hirota

Journal:

Toxicology Letters

Year:

1997

Language:

english

File:

PDF, 446 KB

english, 1997

16

Effects of Methylxanthine Derivatives on Adriamycin Concentration and Antitumor Activity

Yasuyuki Sadzuka, Ayano Iwazaki, Atsuo Miyagishima, Yasuo Nozawa, Sadao Hirota

Journal:

Year:

1995

File:

PDF, 404 KB

1995

17

Dielectric Studies of Colloid-Chemical Stability of W/O Type Anti-inflammatory Emulsive Preparations

KANEKO, HIDEO, HIROTA, SADAO

Journal:

YAKUGAKU ZASSHI

Year:

1986

Language:

english

File:

PDF, 783 KB

english, 1986

18

Effect of CPT-11 on Lipid Peroxide Level in Mouse Tissues

Yasuyuki Sadzuka, Sadao Hirota

Journal:

Year:

1997

File:

PDF, 262 KB

1997

19

Bone lesions and dental caries after gastrectomy

Minoru Fukuda, Masaki Hirota, Sadao Sato

Journal:

Year:

1986

Language:

english

File:

PDF, 331 KB

english, 1986

20

Effect of crystallinity on the percutaneous absorption of corticosteroid. I. Determination of the degree of crystallinity of hydrocortisone acetate in ground mixtures with crystalline cellulose.

MORITA, MASAMI, HIROTA, SADAO, KINUNO, KOUJI, KATAOKA, KATSUO

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1985

File:

PDF, 575 KB

1985

21

An Importance of Colloid Chemical Characterization of Liposomes for DDS in a Large Scale Production

Journal:

YAKUGAKU ZASSHI

Year:

1997

File:

PDF, 1.41 MB

1997

22

Purification and characterization of a pepsinogen and its pepsin from proventriculus of the Japanese quail

Hiroyasu Esumi, Sadao Yasugi, Mizuno Takeo, Hirota Fujiki

Journal:

Biochimica et Biophysica Acta (BBA) - Enzymology

Year:

1980

Language:

english

File:

PDF, 472 KB

english, 1980

23

Mechanical complex formation of tolbutamide with β-cyclodextrin by solid phase roll mixing

Yasuo Nozawa, Hideki Nawa, Yasuyuki Sadzuka, Atsuo Miyagishima, Sadao Hirota

Journal:

Pharmaceutica Acta Helvetiae

Year:

1997

Language:

english

File:

PDF, 545 KB

english, 1997

24

Effect of liposomalization on the antitumor activity, side-effects and tissue distribution of CPT-11

Yasuyuki Sadzuka, Sachiyo Hirotsu, Sadao Hirota

Journal:

Year:

1998

Language:

english

File:

PDF, 310 KB

english, 1998

25

Alopecia of IFN- γ Knockout Mouse as a Model for Disturbance of the Hair Cycle: A Unique Arrest of the Hair Cycle at the Anagen Phase Accompanied by Mitosis

Hirota, Ryuichiro, Tajima, Sadao, Yoneda, Yukio, Tamayama, Takumi, Watanabe, Masahito, Ueda, Kouichi, Kubota, Takahiro, Yoshida, Ryotaro

Journal:

Journal of Interferon & Cytokine Research

Year:

2002

Language:

english

File:

PDF, 1.16 MB

english, 2002

26

Comparison of the shape parameters of DNA–cationic lipid complexes and model polyelectrolyte–lipid complexes

Yan Sun, Xingju Yu, Yasuyuki Takaoka, Sho-ichi Oh-i, Nejat Dűzgűneş, Sadao Hirota

Journal:

Journal of Colloid and Interface Science

Year:

2004

Language:

english

File:

PDF, 352 KB

english, 2004

27

Mechano-chemical formation of indomethacin β cyclodextrin inclusion compounds in powder phase roll mixtures

Yasuo Nozawa, Yoshio Morioka, Yasuyuki Sadzuka, Atsuo Miyagishima, Sadao Hirota, J.Keith Guillory

Journal:

Pharmaceutica Acta Helvetiae

Year:

1997

Language:

english

File:

PDF, 555 KB

english, 1997

28

Stability of Ascorbic Acid in Fused System Containing Ascorbic Acid and Mannitol

OSUGI, SATOSHI, HAYASHI, TAIZO, HIROTA, SADAO

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1968

File:

PDF, 410 KB

1968

29

Estimation of the degree of crystallinity and the disorder parameter in a drug by an X-ray diffraction method with a single sample.

MORITA, MASAMI, HIROTA, SADAO

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1982

File:

PDF, 831 KB

1982

30

Dielectric studies on emulsion of aqueous agarose gel in hydrophobic colloidal silica-oil gel.

KANEKO, HIDEO, HIROTA, SADAO

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1985

File:

PDF, 1.61 MB

1985

31

Viscosity Measurement of Non-Newtonian Liquid by Falling. sphere Method

TAKADA, Masao, HIROTA, Sadao

Journal:

Nippon kagaku zassi

Year:

1959

File:

PDF, 666 KB

1959

32

Effect of Polyethyleneglycol (PEG) Chain on Cell Uptake of PEG-Modified Liposomes

Sadzuka, Yasuyuki, Kishi, Kaori, Hirota, Sadao, Sonobe, Takashi

Journal:

Journal of Liposome Research

Year:

2003

Language:

english

File:

PDF, 424 KB

english, 2003

33

Effects of particle size and stabilizing agents upon dielectric properties of water-in-oil type emulsions.

KANEKO, HIDEO, HIROTA, SADAO

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1985

File:

PDF, 1.43 MB

1985

34

Effect of crystallinity on the percutaneous absorption of corticosteroid. II. Chemical activity and biological activity.

MORITA, MASAMI, HIROTA, SADAO

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1985

File:

PDF, 702 KB

1985

35

[Methods in Enzymology] Liposomes, Part A Volume 367 || Viscometric Determination of Axial Ratio of Ellipsoidal DNA–Lipid Complex

Year:

2003

Language:

english

File:

PDF, 253 KB

english, 2003

36

Dielectric studies on emulsion of water in hydrophobic colloidal silica-oil gel.

KANEKO, HIDEO, HIROTA, SADAO

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1983

File:

PDF, 3.21 MB

1983

37

Towards new products for human health

Journal:

Advanced Drug Delivery Reviews

Year:

1997

Language:

english

File:

PDF, 149 KB

english, 1997

38

Texture study on optimum formulation of molded poultices.

KURODA, MINORU, KANEKO, HIDEO, HIROTA, SADAO, OHNO, YOSHIO

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1986

File:

PDF, 659 KB

1986

39

Effects of mixed polyethyleneglycol modification on fixed aqueous layer thickness and antitumor activity of doxorubicin containing liposome

Yasuyuki Sadzuka, Akiko Nakade, Rieko Hirama, Atsuo Miyagishima, Yasuo Nozawa, Sadao Hirota, Takashi Sonobe

Journal:

International Journal of Pharmaceutics

Year:

2002

Language:

english

File:

PDF, 237 KB

english, 2002

40

Effect of sterical stabilization on macrophage uptake in vitro and on thickness of the fixed aqueous layer of liposomes made from alkylphosphocholines

Reiner Zeisig, Kazuhiko Shimada, Sadao Hirota, Dieter Arndt

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

1996

Language:

english

File:

PDF, 457 KB

english, 1996

41

Effective Irinotecan (CPT-11)-containing Liposomes: Intraliposomal Conversion to the Active Metabolite SN-38

Yasuyuki Sadzuka, Sachiyo Hirotsu, Sadao Hirota

Journal:

Year:

1999

Language:

english

File:

PDF, 412 KB

english, 1999

42

Induction of Hair Regrowth in the Alopecia Site of IFN-γ Knockout Mice by Allografting and IFN-γ Injection into the Transplantation Site

Hirota, Ryuichiro, Tajima, Sadao, Yoneda, Yukio, Okada, Masashi, Tashiro, Junko, Ueda, Kouichi, Kubota, Takahiro, Yoshida, Ryotaro

Journal:

Journal of Interferon & Cytokine Research

Year:

2003

Language:

english

File:

PDF, 782 KB

english, 2003

43

Dielectric studies on emulsion of water in hydrophobic colloidal silica-oil gel. II.

KANEKO, HIDEO, HIROTA, SADAO

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1984

File:

PDF, 644 KB

1984

44

Protection against cisplatin-induced nephrotoxicity in the rat by inducers and an inhibitor of glutathione S-transferase

Sadzuka Yasuyuki, Shimizu Yoshihiko, Taking Yoshio, Hirota Sadao

Journal:

Biochemical Pharmacology

Year:

1994

Language:

english

File:

PDF, 653 KB

english, 1994

45

Biodistribution of liposomes containing synthetic galactose-terminated diacylglyceryl-poly(ethyleneglycol)s

Kazuhiko Shimada, Jan A.A.M Kamps, Joke Regts, Kiyoshi Ikeda, Tatsushi Shiozawa, Sadao Hirota, Gerrit L Scherphof

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

1997

Language:

english

File:

PDF, 353 KB

english, 1997

46

The Study of Polyethyleneglycol-Coated Liposomes Containing CPT-11

Sadzuka, Yasuyuki, Hirotsu, Sachiyo, Miyagishima, Atsuo, Nozawa, Yasuo, Hirota, Sadao

Journal:

Journal of Liposome Research

Year:

1997

Language:

english

File:

PDF, 805 KB

english, 1997

47

Effects of administered route on tissue distribution and antitumor activity of polyethyleneglycol-coated liposomes containing adriamycin

Yasuyuki Sadzuka, Shin-ichiro Nakai, Atsuo Miyagishima, Yasuo Nozawa, Sadao Hirota

Journal:

Year:

1997

Language:

english

File:

PDF, 3.15 MB

english, 1997

48

Does the amount of an antitumor agent entrapped in liposomes influence its tissue distribution and cell uptake?

Yasuyuki Sadzuka, Sadao Hirota

Journal:

Year:

1998

Language:

english

File:

PDF, 137 KB

english, 1998

49

Editorial [Hot Topic: Physico-chemical Approach to Targeting Phenomena (Guest Editors: Sadao Hirota and Nejat Duzgunes)]

Hirota, Sadao, Duzgunes, Nejat

Journal:

Current Drug Discovery Technologies

Year:

2011

Language:

english

File:

PDF, 28 KB

english, 2011

50

Effects of Methylxanthine Derivatives on Antitumor Activity and Toxic Side Effect of Adriamycin Induced by Inhibition of DNA Biosynthesis

SADZUKA, Yasuyuki, IWAZAKI, Ayano, HIROTA, Sadao

Journal:

YAKUGAKU ZASSHI

Year:

1998

File:

PDF, 959 KB

1998

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